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Molecular topography of an entire nervous system. TGM4: an immunogenic prostate-restricted antigen. J Immunother Cancer. Dynamic landscape of protein occupancy across the Escherichia coli chromosome. PLoS Biol. Breast Cancer Res Treat. Dimerization of Cadherin involves multi-site coupled unfolding and strand swapping. Nat Commun. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. Mol Cancer Ther.
Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages. Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker. Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia. J Immunol. Integrating 3D structural information into systems biology.
J Biol Chem. An expanded universe of cancer targets. Cancer Immunol Res. Functional interrogation of DNA damage response variants with base editing screens. Joseph TA, Pe'er I. Methods Mol Biol. Global Patterns of Recombination across Human Viruses. Mol Biol Evol.
Comprehensive characterization of protein-protein interactions perturbed by disease mutations. Nat Genet. Liu Z, Rabadan R. Computing the Role of Alternative Splicing in Cancer. Prioritizing transcriptional factors in gene regulatory networks with PageRank. Cancer Discov. A modular master regulator landscape controls cancer transcriptional identity. Genome Biol Evol. Dose-response modeling in high-throughput cancer drug screenings: an end-to-end approach.
J Cell Biol. A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression. EMBO J. Cell Syst. Cell Rep. Blood Cancer Discov. Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.
Patterns N Y. Stem Cell Reports. Yang J, Tavazoie S. Regulatory and evolutionary adaptation of yeast to acute lethal ethanol stress. PLoS One. Correction: Secretome analysis of patient-derived GBM tumorspheres identifies midkine as a potent therapeutic target. Exp Mol Med. Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.
High tumor mutational burden and T-cell activation are associated with long-term response to anti-PD1 therapy in Lynch syndrome recurrent glioblastoma patient. Cancer Immunol Immunother. Exons as units of phenotypic impact for truncating mutations in autism. Mol Psychiatry. Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat Med. Wang G, Anastassiou D.
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